Mark Twain lived in Buffalo from 1869-1871. This is significant in that it shaped him as a writer and as a person.
His time in Buffalo was the longest period that Twain had lived in one place since early childhood. Buffalo was the first place he lived as a married man, the birthplace of his first child, the first place he owned a home (truth here is his new bride and father-in-law conspired to buy the house, a luxury that a fledgling newspaper man could not easily afford) and the first place that he became co-owner of a newspaper. Buffalo was a place of many “firsts” in Samuel Clemens life.
Though a time of great productivity for Twain, it was also a period of his greatest tragedies. His father-in-law died from cancer and his wife Olivia (Livvy) from Typhoid. His son Langdon died tragically early in his life as well.
There is a collection of his writings from this traumatic period, entitled Mark Twain at The Buffalo Express: Articles and Sketches by America’s Favorite Humorist (Northern Illinois University Press; 1999).
Mark Twain honed his writing acumen in Buffalo during his time as the editor of The Buffalo Express newspaper, (he often collaborated on articles and columns with Joseph Larned, his co-editor and friend).
For more on Samuel Clemens (Mark Twain) click here.